Jose Santiago
- Given Name
- Jose Guillermo
- Nickname(s)
- Pantalones
- Born
- 9/4/1928 — Coamo, P.R.
- Died
- 10/9/2018 — San Juan, P.R.
- Weight
- 175 lbs
- Height
- 5' 10"
- Throws
- R
- Bats
- R
- Team(s)
- Cleveland Indians (1954–1955)Kansas City Athletics (1956)
- Debut
- 1954-04-17
- Final Game
- 1956-07-15